InterBioScreen Monograph Series

SELECTED METHODS
FOR SYNTHESIS AND MODIFICATION
OF HETEROCYCLES

THE CHEMISTRY AND BIOLOGICAL ACTIVITY
OF NATURAL INDOLE SYSTEMS

Edited by Prof. V.G. Kartsev

International Editorial Board:

Prof. Bergman J. (Sweden)
Prof. Bölcskei H. (Hungary)
Prof. Corey E.J. (USA, Nobel Prize in Chemistry 1990)
Prof. Fraschini F. (Italy)
Prof. Huisgen R. (Germany)
Prof. Katritzky A.R. (USA)
Prof. Knölker H.-J. (Germany)
Prof. Noyori R. (Japan, Nobel Prize in Chemistry 2001)
Prof. Van der Plas H.C. (Netherlands)

4 Volume, 352 pages,
Moscow: Published by the International Charitable Foundation Scientific Partnership (ICSPF), 2005


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SELECTED METHODS
FOR SYNTHESIS AND MODIFICATION
OF HETEROCYCLES

THE CHEMISTRY
AND BIOLOGICAL ACTIVITY
OF NATURAL INDOLE SYSTEMS
(Part 1)


Edited by Prof. V.G. Kartsev




Volume 4




ICFSP
Moscow - 2005

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This volume in the series Selected Methods for Synthesis and Modification of Heterocyles—published by InterBioScreen Ltd. and the International Charitable Foundation Scientific Partnership—is devoted to the chemical behavior and biological activity of naturally occurring indole systems.

The chemistry of indole alkaloids has been under research since the 50s. At that time, the number of such alkaloids did not exceed a mere hundred. To date, indole alkaloids have emerged as probably the largest class of alkaloids (over 1200 compounds) extracted from more than
40 families of plants, micro-, and marine organisms.

This is Part 1 of the vast material on the chemistry of various indole alkaloids selected by the Editorial Board for publication in the series. Volume 4 contains reviews of the state-of-the-art chemistry of indole alkaloids contributed by worldwide recognized experts in the chemistry and biological activity of indole systems, which makes the book useful and instructive for a wide circle of readers.

Part 2, devoted to natural indole systems, is planned to appear in Volume 5 of the series. It will cover the available data on more than 900 alkaloidsbearing the indole moiety, their biosynthesis, stereochemistry, biological activity, mechanism of action, and will also discuss some aspects of total synthesis of indole alkaloids.

Volumes 1, 2 in the series Selected Methods for Synthesis and Modification of Heterocyles appeared in 2003. Volume 1 is a collection of reviews on the synthesis and modification of nitrogen-containing heterocycles while Volume 2, of oxygen- and sulfur-containing heterocycles.

Volume 3 (appeared in 2004) is devoted to the chemistry of synthetic indole systems and covers a wide range of indoles, from simple representatives of this class to more complicated (largely synthetic) condensed systems.

Volume 4 and the forthcoming Volume 5 are a logical continuation of our previous publications focused on natural indole systems. Symbolically, this volume is being issued in the year of the 90th Anniversary of birthday of my great and dear Teacher, Prof. A.N. Kost, who worked at Moscow State University and greatly contributed to the chemistry of indole and its derivatives.

In 2006–2007, we are planning to publish the next volumes that will overview the most recent advances in the chemical behavior and biological activity of carbolines (Volume 6), isoquinolines (Volume 7), and quinolines (Volume 8).

 

V. Kartsev 

Moscow, December 2005


CONTENTS
VOLUME 4

Aripova S.F., Kartsev V.G.1, Khuzhaev V.U.
Natural simple indole alkaloids

7

Bölcskei H.
Ibogamine/catharanthine-type indole alkaloids
and their synthetic derivatives (Part I)

38
Bölcskei H.
Ibogamine/catharanthine-type indole alkaloids
and their synthetic derivatives (Part II)

49
Bölcskei H.
Vinblastine-type indole-indoline alkaloids and their derivatives
71
Bölcskei H.
Ergot alkaloids and their synthetic derivatives
108
Fraschini F., Demartini G., Lucini V., Spadoni G., Bedini A.,
Guidi T., Tarzia G., Esposti D.
Synthesis and biology of melatonin and related indole analogs
132
Knölker H.-J., Reddy K.R.
Total synthesis of furocarbazole alkaloids
166
Lakatosh S.À., Preobrazhenskaya Ì.N.
Synthesis of indolo[2,3-a]pyrrolo[3,4-c]carbazoles,
related bis(indol-3-yl)maleimides, and their analogs
182
Shults E.E., Tolstikov G.A.
Tremorgenic indole alkaloids
241
Stonik V.A., Radchenko O.S.
Marine alkaloids, including bioactive indole derivatives
287
 

Author index

336

 


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