The First International Conference on
"Chemistry and Biological Activity
of Nitrogen-Containing Heterocycles and Alkaloids"
OVERVIEW OF THE RESULTS
October 9-12, 2001
Russian Academy of Public Administration under President of Russian Federation
This representative forum of scientists from Russia, C.I.S. and Baltic states has marked the beginning of a series of international scientific conferences on The Chemistry and Biological Activity of Synthetic and Natural Compounds.
The conference has been convened and organized by "InterBioScreen Ltd." and "Scientific Partnership" Charitable Foundation, with the aid and support from the Russian academy of Sciences (RAS), Lomonosov Moscow State University and Moscow government.
Head of the Organizing committee - Dr. Victor G. Kartsev, CEO & Vice-President of InterBioScreen Ltd.
The scientific advisory committee of the conference was composed of eminent scientists from Russia and the C.I.S. engaged
in research in the chemistry and biological activity of synthetic and natural heterocyclic compounds.
Sergei A. ANDRONATI, Director, Institute of Physical Chemistry, National academy of Sciences of Ukraine
Irina P. BELETSKAYA, Moscow State University
Oleg N. CHUPAKHIN, Director, Institute of Organic Synthesis, Ural Branch, Russian academy of Sciences
Georgii B. ELYAKOV, Vice-President, Far-Eastern Branch, Russian academy of Sciences
Vladimir G. GRANIK, Department of Medical Chemistry, Research Center NIOPIK, Moscow
Igor A. GRIGOR'EV, Deputy Director, Institute of Organic Chemistry, Siberian Branch, Russian academy of Sciences,Novosibirsk
Boris A. IVIN, Pharmaceutical academy, St. Petersburg
Valeri P. KUKHAR', Director, Institute of Bioorganic Chemistry and Petrochemistry, National academy of Sciences of Ukraine
Vladimir I. MINKIN, Director, Institute of Physical and Organic Chemistry, Rostov State University
Lev A. PIRUZYAN, Director, Center for Theoretical Problems of Physicochemical Pharmacology
Vladimir V. POROIKOV, Institute of Biomedical Chemistry, Russian academy of Medical Sciences, Moscow
Genrikh A. TOLSTIKOV, Director, Institute of Organic Chemistry, Siberian Branch, Russian academy of Sciences
Boris A. TROFIMOV, Director, Institute of Chemistry, Siberian Branch, Russian academy of Sciences
Marat S. YUNUSOV, Director, Institute of Organic Synthesis, Ural Branch, Russian academy of Sciences, Ufa
Nikolai S. ZEFIROV, Director, Institute of Physiologically Active Compounds, Chernogolovka, Moscow
Members of Organizing, Program and Publication committees:
Owing to the interdisciplinary character of the conference, the scientists who work in various fields of organic chemistry
of biologically active compounds have obtained the wonderful possibility to report their findings and achievements related
to the synthesis, structural studies, biological activity, theoretical medicinal chemistry, as well as to exchange views
on a number of topical problems in the scientific and business cooperation in interdisciplinary areas.
The conference has assembled the "best of the best" and become the most representative forum of the leading scientists
from all regions across Russia and C.I.S. states (Ukraine, Belarus, Kazakhstan, Uzbekistan, Georgia, Tajukistan, Kirghizia,
Latvia). The attendance was over 300 delegates from 77
cities and 140 leading research institutes of Russia and abroad.
InterBioScreen Ltd was the major organizer and sponsor of the Conference . Financial support has been given by the Scientific Partnership Charitable Foundation, Moscow Committee for Science and Technology, Matrix Technologies Corporation, Sigma-Aldrich, ChemNavigator (USA), Summit Pharmaceuticals International Corporation (Japan), from several Russian and Ukrainian companies such as DIAeM - Laboratory (Moscow), OST group of enterprises (Chernogolovka), Enamine, EõiMed (Êiev, Ukraine).
At the opening ceremony, the Conference delegates were welcomed by members of the academy of Sciences G.À. Tolstikov, S.À. Andronati, V.À. Tartakovsky, N.S. Zefirov, I.P. Beletskaya.
During the Conference,
a special awarding ceremony was held at which Gold medals
For Contribution to Science and Scientific Partnership
established by Scientific Partnership Foundation
were presented to a number of research institutes and organizations
along with nominal stipends for gifted graduates and students.
Awards were presented to:
For Contribution to Science and Scientific partnership
was awarded to
Program of the conference included
The oral and poster lectures were addressed to the most interesting topics related to the synthesis methods and properties
of novel heterocyclic compounds, their biological activity and also highlighted research results in boundary areas between
chemistry of synthetic and natural heterocycles, and medicinal chemistry and pharmacology.
The high scientific level and a wide coverage of topics have been set by the outstanding plenary speakers. The plenary lectures were presented by:
Adekenov S.M. ("Perspectives for development of new drugs based on alkaloids and nitrogen-containing terpenoids"),
Andronati S.A., Makan S.Yu. ("Nitrogen-containing heterocyclic compounds as ligands for serotonin receptors"),
Akhrem A.A., Gulyakevich O.V., Mikhal'chuk A.L. ("Synthesis of condensed quinolizine derivatives through annelation
of cyclic Schiff bases: [2+4]-cyclocondensation"), Belen'kii L.I., Poddubnyi I.S., Luiksaar S.I., Krayushkin
M.M. ("Trichloromethylarenes in synthesis of 1,3,4-oxadiazoles"), Granik V.G. ("Nenitzescu reaction:
A new approach to synthesis of annelated 5-hydroxy-indoles and -benzofurans"), Dovlatyan V.V. ("Reactions
of functionally substituted azines"), Drach B.S., Brovarets V.S., Smolii O.B. ("Phosphonium reagents for
synthesis of nitrogen-containing heterocycles"), Elyakov G.B., Radchenko O.S., Balaneva N.N., Novikov V.L. ("Marine
alkaloids: Chemistry and pharmacology"), Zefirov N.S., Palyulin V.A. ("Quantitative structure-activity
relationship studies on nitrogen-containing heterocyclic compounds"), Ivin B.A. ("New reactions of heteroazines
as a route to bioactive azoles and azines"), Kartsev V.G. ("Biological activity and new trends in the chemistry
of isoquinoline alkaloids"), Kostyanovsky R.G., Kostyanovsky V.R., Kadorkina G.K., Torbeev V.Yu. ("New
routes to chiral drugs"), Mezheritskii V.V. ("Chemistry of 1H-1,2-diazaphenalene"), Poroikov V.V.,
Filimonov D.A. ("Computer-assisted prediction of biological activity in a search for and optimization of new drugs"),
Praliev K.D. ("Ñ- and N-substituted mono- and bicyclic pyperidines: Synthesis, stereochemistry, transformations,
and properties. New synthetic analgetics and anesthetics"), Tolstikov G.A., Shults E.E., Chernov S.V., Tolstikova
T.G., Sorokina I.V., Shakirov M.M., Mamatyuk V.I. ("Synthesis of alkaloid-like compounds from diterpenic acids: A new
group of nootropic agents"), Khilya V.P., Kupchevskay I.P., Grishko L.G. ("Reactions of modified isoflavones
with hydrazine and its derivatives"), Khoshtariya T.E. ("Synthesis, properties, and biological activity
of benzo[b]furo-, benzo[b]-thiophene-, dioxodihydro-1H-benzo[b]furo-, dioxohydro-1H-benzo[b]-thiopheneindoles and their
derivatives"), Charushin V.N., Chupakhin O.N. ("Ortho-, meta- and para-cyclization in structural modification
of p-deficient azaaromatics"), Chupakhin O.N., Fedorova O.V., Rusinov G.L. ("Lipophilic nitrogenous heterocycles
as a promising class of antituberculosis agents"), Shakhidoyatov Kh.M. ("Chemical transformations of tricyclic
quinazoline alkaloids"), Shults E.E., Tolstikov G.A., Shakirov M.M., Tolstikova T.G. ("Synthesis of thebaine-derived
m-opioid receptor agonists"), Yunusov M.S. ("Alkaloids as biologically active compounds")
The remarkable 62 talks by the leading scientists from Russia and CIS gave the state-of-the-art picture of Chemistry and Biological Activity of Nitrogen-Containing Heterocycles andAlkaloids
Nitrogen-containing Heterocycles and Alkaloids.
The conference proceedings have been published in two volumes, both in Russian and English under the title "Nitrogen-containing heterocycles and alkaloids". This edition of superb quality opens a series of annual publications Chemistry of Biologically Active Synthetic and Natural Compound (CBC).
Volume 1 (564 pages) contains plenary and oral presentations devoted to the state-of-the art in this field. Volume 2 (475 pages) contains summaries of poster presentations and 100 the most interesting and original methods of synthesis and modification of complex heterocyclic compounds developed by CIS scientists.
Two volume proceedings of the conference in English and Russian are also available on CD-ROM released by Iridium Press Publishers.
The editorial board of this periodic publication:
Abduvakhabov À.À., member of academy, Uzbekistan
Minkin V.I., member of academy, Russia
On the initiative of InterBioScreen Ltd, for the first time ever the conference featured an exhibition-library of unique scientific literature published by foreign and home publishing houses.
During the conference a face-to-face meeting was organized for the members of the editorial staff of the Journal for Chemistry
of Heterocyclic Compounds and the authors who contributed papers to the Journal.
At the closing ceremony of the conference Chemistry and Biological Activity of Nitrogen-Containing Heterocycles and Alkaloids, based on the results of the opinion poll of the delegates, the authors of the best works have been awarded
a Memorial Gold medal
For Contribution to Science and Scientific partnership
For the best plenary lecture:
- Vladimir G. GRANIK, professor (Moscow)
- Boris S. DRACH, professor (Kiev)
- Georgii B. ELYAKOV, member of academy, Russia (Vladivostok)
- Boris A. IVIN, corresponding member of the academy, Russia (St. Petersburg)
- Rem G. KOSTYANOVSKII, professor (Moscow)
- Vladimir P. KHILYA, corresponding member of the academy, Ukraine (Kiev)
For the best oral presentation:
- Demchenko A.M. and co-authours (Chernigov);
- Kalinin V.N. (Moscov);
- Kaminskii V.S. and co-authors (Vladivostok);
- Krasnov K.A. and co-authors (St. Petersburg);
- Makarevich I.F. and co-authors (Khar'kov);
- Mironov V.F. and co-authors (Kazan');
- Parkhomenko P.I. and co-authors (Kiev);
- Tyurina L.A. and co-authors (Ufa);
For the best poster presentation:
- Brovarets V.S. and co-authors (Kiev);
- Garazd M.M. and co-authors (Kiev);
- Silin A.V. and co-authors (Khar'kov);
- Khlestkin V.K. and co-authors (Novosibirsk);
- Sham'yanov I.D. and co-authors (Tashkent);
and Memorial Gold Medals
for particular contribution to the development of the advanced methods of synthesis and modification of heterocycles
have been presented to:
- Research group:
Noravgan A.S., Paronikyan E.G., Mkrtchyan A.P., Oganisyan A.Sh., Sirakanyan S.N.,
Institute of Fine Organic Chemistry, National academy of Sciences of Armenia
- Research group
Mikhailovskii A.G.(1), Syropyatov B.Ya.(2), Dolzhenko A.V.(2), Shklyaev V.S.(1)
1)Institute of Technical Chemistry, Ural Branch, Russian academy of Sciences (Perm')
2)State Pharmaceutical academy (Perm')
- Research group:
Maslivets A.N., Krasnykh O.P., Konyukhova N.A.,
Perm' State University
- Research group:
Sipkin D.I., Molchanov A.P., Koptelov Yu.B.
St. Petersburg State University (St. Petersburg)
- Research group:
Gazaliev A.M., Fazylov S.D., Nurkenov O.A., Kasenov R.Z., Zhurinov M.Zh.
Institute of Organic Synthesis and Coal Chemistry, Karaganda (Kazakhstan)
All Photos from the Conference
The Next International Conference of the series
will be held in 2003
and will be devoted
to Oxygen and Sulphur-bearing synthetic
and natural heterocycles